Trafford-based Russells Construction has started work on a new Greene King pub and McDonald's restaurant on former industrial land in the south Cheshire town.
The three-acre plot was sold by engineering firm Bombardier and is to the North West of its current facility, off Dunwoody Way.
Russells started remediation works and will install the foundations and service infrastructure for the two new buildings, including a new road layout. Greene King will start work on the 7,500 sq ft pub in July, as will McDonalds.
Andrew Russell, director of Russells Construction, said: "We are on site preparing the land for development with the installation of services and infrastructure to support the new occupiers, and in doing so regenerating a brownfield site. We're also preparing the rest of the site for future occupation, ensuring it is oven ready for development."
Sister company Russell Homes secured the deal with both operators. The firm is currently marketing the adjacent 2.5-acre plot for food, retail, or leisure use.
Russell Homes also brought forward a neighbouring site for residential use with Countryside Properties, which is now building 143 affordable properties.
Daniel Kershaw, land director at Russell Homes, said: "This is a strategic site in the heart of Crewe near to existing retail and leisure outlets and was ideal for a mixed use development with long term economic benefits, which aligns with the aspirations of the local authority. Together with Countryside Properties we have brought forward more than 140 new homes to provide affordable properties and increased choice for the local community."