The vehicle rental company intends to build three industrial units totalling 90,000 sq ft on land formerly occupied by AstraZeneca off Brightside Road at North Manchester Business Park.
In 2019, Manchester City Council granted Salford Van Hire permission for the first phase of the project, an MOT and maintenance facility on a 13-acre plot bordering the River Irk close to North Manchester General Hospital in Crumpsall.
The first phase is due for completion this spring.
The second phase comprises three units ranging from 19,400 sq ft and 40,000 sq ft on a 5.8-acre adjoining plot to the west of the first phase.
Fletcher Rae is the architect for the project.
In 1917, the site was developed as part of the British Dyestuffs Corporation, which later became AstraZeneca.
The buildings were demolished in the 1980s and Harrow Estates purchased the site from AstraZeneca in 2004. The land was then remediated before Salford Van Hire bought it in 2016.