Thornham Mill on Oozewood Road in the Oldham suburb would be demolished and replaced with a 72-home apartment block, under plans lodged with Oldham Council.
The plans, a rejig of proposals approved more than a decade ago, were submitted by Blackmores Planning and Development on behalf of a private landowner.
Calderpeel Architects, which was behind the 2007 designs, has also been appointed to draw up the latest iteration of the project.
Under the plans, the 19th-century mill would be demolished and a five-storey block built in its place.
The building would feature a mix of one-, two- and three-bedroom apartments, as well as 69 basement parking spaces and an additional 18 surface level spaces to the rear of the property.
Built in 1885 by Thornham Spinning Co, the majority of the mill building has been vacant since 1962 when the company went into voluntary liquidation, according to Calderpeel.