Stockport Council has approved plans from Muse Developments for a hotel and a 43,000 sq ft office in the Stockport Exchange scheme.
The project is the second phase of Stockport Exchange scheme, after the development of a multi-storey car park was completed earlier this year.
The office building will provide about 43,000 sq ft of office accommodation with 6,350 sq ft of retail space on the ground floor while the hotel will have 115 bedrooms.
The entire Stockport Exchange development will provide 375,000 sq ft of office space and up to 28,000 sq ft of commercial space.
Wes Erlam, senior development surveyor at Muse, said: "We've already successfully delivered the first phase by way of the new multi-storey car park and gaining outline planning consent for the overall scheme and full permission for phase two is a great achievement.
"We can now focus on the delivery of a grade A, BREAAM Excellent office building, 115-bed hotel and a high quality public area, which we believe will attract businesses to Stockport, aided by the proximity immediately adjacent to the mainline rail station."
Paul Lawrence, director for place at Stockport Council, said: "Stockport Exchange is an integral part of our commitment to invest in Stockport's future, boosting the economy and regenerating the borough. We welcome planning approval and look forward to beginning the phase two development."
CBRE and DTZ are the joint agents for Stockport Exchange and Deloitte has acted as the planning consultant.