Steven Broomhead is stepping down from his position as chief executive of the North West Development Agency at the end of the month.
Speaking at the NWDA annual general meeting, Broomhead, who earned nearly £200,000 a year, said: "My departure news should not distract from our messages today. This year's annual conference and AGM has highlighted our results achieved for the region in the past 12 months.
"The agency has remained focused, adapting quickly and efficiently in order to help regional businesses survive and grow. Indeed, the National Audit Office rated the NWDA's response to recession with the highest grade possible, following an independent review.
"The agency has responded quickly to ever changing economic climate, as well as acting quickly in the face of natural disasters. I am particularly proud of the agency's £1m support package in response to the Cumbrian floods, which could not have been provided by any other organisation. The agency has built a powerful base for generating private investment in the region, including the regional international trade programme, which has safeguarded 2,300 jobs in just three years and provided a return of over £22 for every £1 invested.
"I have enjoyed my time in this role immensely and it has been a privilege to work with so many committed partners and talented staff. The achievements of the agency are there for all to see. However, I feel the time is now right for me to step down and get a better work/life balance after seven and a half years in a very busy and demanding role. The agency has a strong executive team which will continue to ensure a smooth transition and closure, working closely with government and our many partners in the region."
The NWDA said it hopes to replace Broomhead soon and is working with the Government's Department for Business, Innovation and Skills to agree future succession arrangements.
There is currently 363 staff at the NWDA. A total of 93 have taken voluntary redundancy since the general election in May.