The online car rental agency Travel Jigsaw has taken 63,096 sq ft at Sunlight House, Manchester, on a five-year lease at a headline rent of £16/sq ft.
Sunlight House, Spinnigfields, is owned by Apia Regional Office Fund, which is managed by Aviva Investors and Warner Estate Holdings.
The deal is claimed to be the largest letting in Manchester for over two years.
Existing occupiers St James's Place Wealth Management, which has 14,100 sq ft, and Charles Stanley Group, which has 5,200 sq ft, have both recently signed new 15-year leases.
In addition there has been three further lettings totalling 5,000 sq ft to The Industrial Tomography Systems, Romero Insurance and Football for Football.
The property's occupancy rate now stands at 95%.
Charlie Royle, asset manager for Apia Regional Office Fund, said: "These transactions are testament to the building's central location and quality of accommodation. Our proactive asset management strategy, with improving facilities and refurbishment of several floors, has enabled us to attract new occupiers in spite of challenging market conditions."
Apia's letting agents on the building are OBI Property Ltd, Canning O'Neil and DTZ.