Developer Nikal will shortly begin demolition of two Trafford Council-owned buildings to pave way for Altrincham's £100m Altair development.
Oakfield House and the former Nationwide Auto Centre on Oakfield Road will be demolished to clear the five acre site near the town centre.
Nikal plans a retail-led scheme also including offices, a hotel and a new permanent ice rink along with new public public realm and improved public transport links at Altrincham Interchange.
The scheme is also shortlisted by Trafford Healthcare NHS Trust as one of two possible locations for the new Altrincham General Hospital. An announcement is expected in November 2010.
Nikal managing director Nick Payne said: "The demolition of these buildings is where we hope Altrincham General Hospital will be built if we win the tender. The development will be the catalyst for the renaissance of Altrincham, leading to a permanent ice rink, offices, hotel and shopping, as well as the proposed new interchange. We hope to be on site with the first phase of development early in 2011 with the first phase open to the public by summer 2012."
Cllr Michael Cornes, executive member for economic growth and prosperity, said: "It is encouraging to see work progressing on the Altair site, bringing the creation of jobs and regeneration of this area a step closer to reality. This scheme will be a real boost for Altrincham enhancing it as a modern and vibrant destination for visitors, shoppers and local people."
Trafford Council are advised by Drivers Jonas Deloitte and Nabarro LLP.