Salford City Council is expected to approve the development of 995 apartments on a site between the River Irwell and Chapel Street.
The plans from developer Dandara involve a 4.2-acre site next to the Lowry Hotel, Century Building and Trinity Bridge House.
The development would see the demolition of existing office and warehouses buildings and the relocation of the Lowry car park, to make way for four buildings of between 12 and 22 storeys.
The scheme would include a mix of studio, one-, two- and three-bedroom apartments for private rent. There would be 15,800 sq ft of commercial units on the ground floor.
In a report ahead of a meeting of the Salford City Council planning committee on Thursday 15 January, officers recommended the scheme be approved and said that "the proposed development would improve the street scene and would have no significant detrimental effect on any designated heritage assets or on any neighbours".
The site benefits from existing planning consent granted in 2007 for a similar scheme, designed by Hodder + Partners. The proposals were never progressed due to the economic downturn.
CBRE, PPS Group and Axis Mason advise Dandara.