The housebuilder has begun construction on its Harts Mead development at the 15-acre site of the former Hartshead High School off Lees Road and Greenhurst Road.
The development in Ashton-under-Lyne comprises 195 homes, 15% of which are to be designated as affordable.
Under the plans, the housing mix includes one-bedroom apartments, as well as semi-detached and detached two-, three- and four-bedroom homes.
Taylor Wimpey bought the site from Tameside Council for £9.4m in 2019.
The school buildings were demolished after Hartshead High School merged with Stamford High School in September 2008 and moved to a new building on Broadoak Road.
Chloe Dunn, sales and marketing director for Taylor Wimpey Manchester, said: “Notwithstanding their proximity to Manchester city centre, these new homes will be ideally positioned for access to a range of local shops and services.
“They are also within the catchment area of ‘outstanding’ Ofsted-rated primary and secondary schools, making it a much sought-after location.”
Play facilities and areas of green space in the scheme will be accessible to all local residents, not just those living at the Harts Mead development, according to Taylor Wimpey.
Baldwin Design Consultancy, Taylor Wimpey’s retained architect, designed the scheme, and Avison Young is the planning consultant.