Manchester City Council is looking for a property manager to look after the Sharp Project media centre.
It has put the 18-month contract out to tender and is seeking, "an innovative and customer-facing management organisation to provide a strategic and operational management function".
The site, a former Sharp Electronics warehouse in east Manchester, was set up three years ago with £16.5m from the council and the European Regional Development Agency to foster media-related start-ups and help regenerate the area.
Some 50 businesses are now based there taking around 75% of the space.
It also has three sound stages which are being used to produce TV shows such as Channel 4's Fresh Meat and Sky's Mount Pleasant.
According to a tender document the management contract will involve running the centre, overseeing existing contracts and developing the Sharp business plan.
"Applicants must have experience and a track record of delivering strategic and operational management of the creative and digital industries sector including managing creative and digital industries sector-focused buildings and managing property and projects."
The development of the site has been led by Sue Woodward while day-to-day management is currently handled by Rose Marley Management which took on the job in May on an interim basis.
The deadline for expressions of interest is January 16.