Knight Frank has been instructed by private clients to dispose of the Department Store on the corner of Thomas Street and Oak Street in Manchester's Northern Quarter.
The fully let building comprises 9,751 sq ft of office and retail accommodation and is available on a freehold basis.
Tenants include Ebden, Richard Goodall Gallery and the Liverpool & Manchester Design Initiative.
Steve Carrick, investment partner at Knight Frank, said: "Rarely does an asset of this nature come onto the open market. The Department Store is fully let and located in the heart of Manchester Northern Quarter. We are inviting offers in excess of £1.2m."