The engineering and development consultancy has taken a 10 year lease on a 9,000 sq ft office suite in 9 Portland Street, Manchester.
Mott MacDonald is relocating from 111 Piccadilly as part of an expansion strategy.
The 54,941 sq ft sq ft building is owned by a private discretionary fund managed by London & Scottish Investments and has undergone a £1m refurbishment that completed at the beginning of this year.
Occupiers include Evolution Banking, Tastecard and SF Group.
Quoting rents in the building are around £15/sq ft.
Rupert Barron, partner at WHR, said: "We worked closely with Mott MacDonald to satisfy their exact requirement for well-located good quality space, which London and Scottish Investments were able to accommodate resulting in a successful deal for all parties."
DTZ and WHR are the retained joint letting agents for the building.