John Sisk & Son has been appointed by developer Goodman to build the Basford West spine road opening up the 85-acre development site for prospective occupiers.
Work will begin next month on the £7m road, following Cheshire East Council's successful bid to the Department for Transport for 'pinch point' funding in order to ease congestion in the area.
Goodman plans to deliver a mixture of residential, distribution, retail and leisure space.
The 1km road represents a vital link between Gresty Road in Crewe and the Shavington junction of the A500 and will improve access to Crewe railway station and then on into the town centre.
Cllr Michael Jones, leader of Cheshire East Council, said: "This is more fantastic news for Crewe and further proves this council's commitment to helping this town to grow and thrive again.
"It also means Crewe is being taken seriously as a place for investment, because the Government is recognising the town's huge economic potential time-and-time again.
"The road itself will provide excellent local and strategic links to Crewe and Nantwich as well as the A500 and M6. It will ease traffic on the existing roads in the area and offer relief to other routes into Crewe, such as the A5020 and Weston Road."
Work has already started on the Crewe Green Link Road South and M6 J16/ A500 widening scheme and the improvements at M6 J17 to follow this autumn.
The authority is now waiting to hear whether it has been successful in applying for £2.8m to widen the B5078, which leads to the M6 at junction 16 at Barthomley.