Office developer-investor Bruntwood has let 4,868 sq ft at the Manchester city centre building to Liberty Mutual Insurance.
LMI has signed a 10-year lease for a suite on the 15th floor. Paul Kurgo, managing director of the commercial division at LMI Europe, said: "The first class reception and quality of accommodation with its panoramic views made Lowry House our building of choice.
"We were working to short timescales and we needed a landlord that could deliver – Bruntwood exceeded our expectations."
OBI advised the tenant. DTZ and WHR are retained agents on Lowry House.