Work will begin in early November on a 90,000 sq ft, £30m Asda store in Grange Road, Birkenhead.
Cllr Simon Holbrook, deputy leader of Wirral Council and cabinet member for corporate resources said: "It is great to see Asda back in Birkenhead. This ambitious project will completely transform this part of the town.
"Asda has a proven track record, through their commitment to Local Employment Partnerships, of creating employment opportunities for local people and I know this development will provide a major jobs boost in an unemployment hotspot in Wirral."
Asda plans to open the new store in November 2011.