The high-end Asian restaurant is tipped to open within No1 The Avenue in Spinningfields once Armani closes its 15,000 sq ft store on 15 August.
Having opened its first site in Mayfair in 2015, the Manchester restaurant will be Sexy Fish’s second venture.
The unit is part of the 50,000 sq ft No1 The Avenue, which features a a distinctive 23-metre cantilever that hangs over Spinningfields Square.
Allied London developed the building, before selling it to IM Properties for £18.6m in 2010.
Current landlord Epic Property Asset Management then acquired the asset from IM for £20m three years later.
Restaurant Australasia occupies the basement, Armani has the ground and first floors, and the offices on the upper floors are home to Brewin Dolphin and Pinsent Masons, among others.
Sexy Fish is part of the Caprice group of restaurants owned by Richard Caring.
Caring also owns The Ivy chain of eateries, one of which opened in Spinningfields in 2019.
Sexy Fish declined to comment on the deal and EPAM was contacted for comment.
As for Armani, there are no immediate plans to for the retailer to relocate in Manchester.
However, the fashion brand was looking at the possibility of moving to New Cathedral Street, Place North West understands.
Sexy Fish’s decision to open a Manchester branch follows a similar move by Boxpark, a street food, retail and entertainment concept previously confined to London.
Place North West revealed last month that Boxpark would open its first site outside the capital within Allied London’s Enterprise City.