The online payment processing company, WorldPay, has taken 22,069 sq ft at 3 Hardman Square in Spinningfields on a 10-year lease at £30/sq ft.
The company will occupy the sixth floor.
CBRE acted on behalf of Müller International, the country asset manager for landlord Credit Suisse Asset Management, Immobilien Kapitalanlagegesellschaft mbH acting for and on behalf of CS-EUROREAL, Open – Ended Real Estate Fund established under the German Investment Act.
Alex Russell, associate director at CBRE, said: "We are delighted to have secured another new tenant for this office building, which follows the recently completed letting to service office operator, i2 Office.
"WorldPay is an important newcomer to city as not only is it set to create at least 200 new jobs but as one of the most successful, independent payment processing companies in the world it will no doubt continue to grow and contribute to the region over the coming years."
Russell confirmed CBRE is currently in discussion with a number of other parties interested in the remaining 120,000 sq ft at 3 Hardman Square.
Stephen Downey, director of GL Hearn, who acted on behalf of WorldPay, said: "Hardman Square presented us with the correct location, image and environment for WorldPay's new Manchester office."