Greater Manchester-based shipping company Tuscor Lloyds has taken 2,620 sq ft on the eighth floor of Peel Group's Quay West on a five-year deal.
The international logistics firm will retain its current building on the Enterprise Trading Estate on Guinness Road, Trafford Park, before moving into Quay West in September.
Nick Rodriguez, from Tuscor Lloyds, said: "At Tuscor Lloyds we constantly seek out new opportunities globally but we have also built strong partnerships with some of the world's largest corporations. Our ethos is reflected by the proud history of the Salford Quays area and the optimism created by its regeneration."
Peel's Quay West is located on Trafford Wharf Road in Trafford.