The developer has submitted plans to deliver around 160 new homes in Openshaw, east Manchester.
Proposals for the 10-acre site, previously used for offices by train manufactures GEC Alstom, were submitted to Manchester City Council by planning consultancy Barton Willmore on St Modwen's behalf.
The scheme aims to complement the adjacent new district centre and provide family accommodation as part of the future regeneration of the area.
Dan Mitchell, planning partner, said: "The proposals for this important site will complement the existing regeneration strategy for the New East Manchester area and build upon the previous redevelopment schemes at Toxteth Street and Ashton Old Road. It will bring new detached and semi detached homes, providing a better mix of local housing stock, including family homes, in a highly accessible location.
"This part of east Manchester is undergoing positive urban renewal and we very much hope that the city council will support this planning application."
Barton Willmore's new office in Spinningfields, Manchester, opened on Tuesday 4 January and is headed up by Mitchell.