Willmott Dixon has finished work on the £18m Archbishop Beck Catholic Sports College in Fazakerley, which will be officially opened by Mayor Joe Anderson on Friday.
The school, which will educate 1,200 pupils, has been built on the former Long Lane council depot.
Archbishop Beck College will relocate from its current site on Cedar Road, Walton.
The new school was designed by architects Sheppard Robson and was engineered by Mouchel.
Willmott Dixon won the contract to build the secondary school for Liverpool City Council in March 2013, as part of the local authority's ongoing programme to rescue projects that stalled when Building Schools for the Future collapsed in 2010.
Anderson said: "The Archbishop Beck Catholic Sports College is a fantastic new facility which will provide thousands of young people with a fantastic education in great surroundings.
"I am really pleased that so many of the subcontracts were awarded to Liverpool firms, meaning that we have been able to recycle millions of pounds back into the city's economy.
"It is also good to see Willmott Dixon have been training the tradespeople of tomorrow by employing apprentices as part of this scheme."
Anthony Dillon, managing director for Willmott Dixon in the North West said: "We're very proud of what we have created with Archbishop Beck, which comes just over a year after we handed over Notre Dame, another brilliant new school for Liverpool.
"As with Notre Dame Catholic College, a key focus was supporting local jobs and companies and I'm pleased to say building Archbishop Beck gave another major boost with 70% of the gross development value spent in the local economy and supply chain. It will be the same approach with Archbishop Blanch, where we are on site now."