Beis Menachem and Yeshivas Lubavitch Manchester have been granted planning permission for the redevelopment of the Beis Menacham School at Park Lane, Broughton Park, to provide a 20,000 sq ft school, synagogue and yeshiva.
The OYY Boys School is due to open in autumn 2016 and will be open to pupils across the world.
The site is currently occupied by the OYY Girls School which will move into its new 10,000 sq ft facility on Bury New Road in autumn 2015.
Euan Kellie Property Solutions advised on the planning application to Salford City Council.
Euan Kellie, director, said: "Gaining planning permission for this important new community facility is the conclusion of a complex but rewarding project with Beis Menacham and the Yeshivas Lubavitch Manchester. The new facilities being created are of international significance."
Designed by Stockport architect Cartwright & Gross, with input from construction consultancy MJ Newton, the new school, Synagogue and Yeshiva will welcome up to 200 pupils in total.
Gary Scorah of Commercial Properties acted on behalf of Beis Menachem and the Yeshivas Lubavitch Manchester.