The discount retail store has taken a 10,000 sq ft premises in the second phase of Ask Developments' project in Urmston town centre.
Quality Save has had a presence in Urmston for 30 years and was historically located in the original precinct and moved to a temporary location on Station Road, occupying the former Woolworths unit, while the redevelopment of the shopping centre took place.
The agreement with Quality Save, along with national supermarket chain Aldi agreed in April, leaves 12,000 sq ft left within phase two of Eden Square.
Developers Ask Developments are currently in advanced stages of negotiations with a national retailer for a third unit comprising 7,500 sq ft and hope to make an announcement shortly.
In the first phase, national charity Shaw Trust, which supports its work with disabled and disadvantaged people to find jobs and live more independently by operating retail shops, has now exchanged contracts on a 1,300 sq ft unit.
Paul Rudkin, managing director of Quality Save, said: "The new unit gives us the chance to offer a wider range of the same quality, low priced goods to our customers in Urmston, many of whom have shopped with us for the 30 years in Urmston. Eden Square is a great location with plenty of free parking spaces and right in the heart of Urmston."
Ask revised plans for phase two of Eden Square in order to respond to current economic conditions and negotiations with a number of retailers which require larger stores than can be accommodated in phase one.
The number of residential units was reduced to 12 from 80 and the retail, of 42,000 sq ft has been reconfigured to allow for larger floorplates.
Retailers in the first phase also include Costa Coffee, Thorntons, Boots, Greggs, Hallmark, HD Studio and William Hill.
Savills and Tushingham Moore are joint letting agents on the scheme. Property consultant Drivers Jonas Deloitte acted as planning consultants.
The cost of the rental agreement was not disclosed.