A group of local residents in Hulme, Manchester has started an online petition against Manchester Metropolitan University's planned £120m Birley Fields campus and is due to hold a public demonstration on Friday afternoon.
The Save Birley Fields campaigners are calling for the proposals to be dropped, claiming consultation was poor, information about its impacts on traffic has not been made available and the existing green space is needed and should not be built upon.
Protestors are being urged to attend a demonstration at 2pm today at Hulme Post Office.
A spokesman for MMU said: "The University has been listening to the Hulme community for well over two years as we recognise the insight of local people is vital.
"The site itself is not natural green space, it is overgrown brownfield, but nevertheless we will be planting more trees than we remove and more than two-thirds of the site will remain open space.
"The 320-space multi-storey which slip-roads onto the Princess Parkway should go some way to keeping parked cars off the streets and we are in negotiations to establish a residents' only parking scheme.
"Extensive consultations show there is a huge amount of support for this scheme within Hulme and beyond because ultimately it is about investing in top quality education for the people of Manchester."
MMU submitted its detailed planning application for the campus for teaching and nursing students last month.