Professional sector organisation Pro Manchester will leave its long-standing home at 81 King Street to move to the ninth floor of Tower 12 in Spinningfields next week.
Pro Manchester joins a rapidly growing tenant list at the refurbished former Manchester House in Allied London's development.
Barristers set Lincoln House Chambers also moved this month to Tower 12. The Chambers, which specialises in regulatory, criminal and civil law, relocated from Brazennose Street.
John Ashcroft, chief executive of Pro Manchester, said: "It's great that we're making the move over to Spinningfields and to Tower 12, it will bring us closer to many of our member firms and is a positive step for our organisation at a time of growth and exciting change, we look forward to becoming part of the bustling hub which is the Spinningfields district."
Michael Ingall, chief executive of Allied London Properties, said: "Tower 12 has attracted many high-calibre businesses and I am delighted to see the space being taken by such varied and dynamic organisations. The feedback from the tenants has been excellent and we have created the innovative workspace which we always wanted to achieve."
Other tenants in the 40,000 sq ft of offices above retail and leisure include Datalex, Barton Willmore, Leonard Curtis and Great Fridays.
OBI Property is sole leasing consultant and project manager on Tower 12. Lincoln House Chambers was advised by Chris Lloyd at DTZ.