Create Developments has submitted an application for a 197-bedroom hotel on land owned by Trafford Housing Trust off Barton Road in Stretford.
The hotel would be situated on a 70,300 sq ft site bounded to the west by the M60 and to the east by Barton Road.
The 12,600 sq ft property would cover one fifth of the overall site, with the remainder given over largely to a 127-space car park.
The AEW-designed development, which would be situated close to the existing Circle Court apartment building, will also feature a restaurant.
A new access point will be created on Barton Road.
A previous planning application, also submitted by the trust as landowner, for two five-storey apartment blocks containing 40 flats was approved in 2017.
Create is currently in talks to purchase the land from the trust in order to bring the hotel forward.
Iceni Projects is consultant on the scheme.
Blackpool-based Create Developments is also nearing completion of a 221-bedroom Hampton by Hilton hotel on Rochdale Road, Manchester, while work on another hotel in Blackpool completed in 2018.
Neither the developer nor consultant would disclose whether or not the Stretford hotel would also be a Hampton by Hilton.