Capital & Centric has received planning approval for its £19m plan to re-develop the Littlewoods Pools Buildings off Edge Lane in Liverpool.
The developer is proposing conversion of the currently derelict building into a 104 bed hotel, 50,000 sq ft of business units and 50,000 sq ft of offices.
Tim Heatley, co-founder of Capital & Centric, said: "These magnificent buildings have been vacant for over ten years, I'm excited by the thought of seeing them full of activity and life again.
"At one time these buildings were host to thousands of people, all processing data for the Littlewoods Pools business.
"This scale of private sector regeneration has been few and far between for the last five years, it's not going to be easy but it's worth the effort to make a step change in such a high profile location."
The current Littlewoods Pools Buildings is owned by the Homes & Communities Agency. The proposal is for Capital & Centric to acquire it with a view to starting on site later this year.
Shed KM is the appointed architect.