The Walton Centre NHS Foundation Trust in Fazakerley, Liverpool, is to establish a construction framework for capital projects.
The trust said it wants to reduce lead times by using an agreed panel of builders and consultants to bid for mini-competitions as work arises.
The Walton Centre is the only stand-alone neurosciences hospital in the country dedicated to caring for people with neurological conditions.
The construction framework will cover three tiers of work: up to £50,000, from £50,000 to £1m, and £1m to £10m. Firms on the contract roster will be in place for four years and deliver all areas of construction, architectural and engineering advice.