Fore Partnership has been given planning permission by Manchester City Council to redevelop 24 Mount Street into office space.
The developer will partially demolish and rebuild the site into 78,000 sq ft of offices, with retail and leisure space, a roof terrace and improvements to the public realm.
The site, formerly known as London Scottish House, is next to the Midland Hotel and Manchester Central convention centre.
The architect is TP Bennett. Fore said it will start on site in October on a 15-month build programme. Kier is the main contractor.
Deloitte provided planning advice. Knight Frank and Lambert Smith Hampton are acting as joint agents for 24 Mount Street.