Notre Dame Catholic College in Everton has opened to staff and pupils.
The £15m school is the first to benefit from Mayor Cllr Joe Anderson's £169m education investment programme.
Situated on Great Homer Street, Everton, Notre Dame is part of the mayor's Investment Plan for Schools, devised as a rescue package after wave six of Liverpool's Building Schools for the Future project was scrapped.
The funding is a combination of city council and Government money and was negotiated as part of Liverpool's City Deal. At least 12 schools will receive investment.
Notre Dame Catholic College has been built by Willmott Dixon, with 60% of the budget for sub-contractors spent with Liverpool companies, including A&B Engineering, Old Swan.
The architect was Sheppard Robson.
The school has space for 1,000 pupils and employs 70 staff. It has been built on a site adjacent to Everton Park Lifestyles Centre.