The station has been closed to all train and tram services for a week following the terrorist attack at the adjoining Manchester Arena last Monday.
Victoria reopened this morning following the lifting of the police cordon, with Northern, TransPennine Express and Metrolink operating a full timetable of services.
City leaders in Greater Manchester have welcomed the reopening.
Mayor of Greater Manchester, Andy Burnham, said: “We continue to grieve with the families of those who died, and support those injured. I’ve been clear that all public bodies must take a families-first approach in the days, months and years ahead to ensure their needs and wishes are fully understood and considered.
“Victoria station’s reopening is an important statement about our city’s recovery from this devastating attack. It continues to send out the message that we will not be bowed, we will not be divided, and we will stand together.”
Public transport users are asked to remain vigilant and report anything suspicious to staff or the police.
For further information about public transport across Greater Manchester visit www.tfgm.com, call 0161 244 1000, or follow @OfficialTfGM on Twitter.