Further sites are to be released to market for residential development after strong sales of new homes on the former Manchester City FC stadium site.
The council has authorised the acquisition of the Stagecoach Bus Depot, which it said "has inhibited housing development in the area due to its unsightly appearance and prominent location".
The council said: "More new housing is needed to meet the needs and aspirations of existing and would-be residents. The current housing range is overwhelmingly smaller terraced properties with low levels of owner occupation."
Next to the bus depot, the site of Bishop Bilsborrow School – which will merge with nearby St Edward's RC School and move to a brand new home on the Maine Road development – will also become available for development.
No sizes were given for the development parcels.
The council is also considering options for the future of the Bowes Street neighbourhood, to the north of the Stagecoach bus depot and south of Claremont Road. This consists of 233 of the poorest quality terraces in Moss Side and some form of intervention is required.