Hitachi Consulting, the strategic business consultancy division of tech giant Hitachi, has taken a 6,000 sq ft office within Bruntwood's Manchester One in Portland Street.
The deal follows Hitachi's move at the end of last year to its new laboratory within the Bruntwood-owned Citylabs site in the Oxford Road corridor.
The 21-storey Manchester One totals 143,000 sq ft, with 4,200 sq ft currently vacant on the top floor.
Quoting rent in the tower begins at £18.50/sq ft.
Brad Topps, head of sales at Bruntwood, said: "Hitachi Consulting is the latest in a long string of new occupiers moving to Manchester One. We put a clear asset management strategy in place at the start of the year and it's great to it coming to fruition for our customer.
"We have welcomed over 30,000 sq ft of occupiers to the building in the last 12 months including Siemens and Greystar."