Liverpool Community Health NHS Trust has signed a 10-year lease for a new 30,000 sq ft base at Liverpool Innovation Park.
The new facility in Edge Lane, Wavertree, will provide the trust with a new head office as well as a base for other services previously based across Merseyside.
The move will bring together nearly 400 LCH staff on one site.
The project was managed by CBRE and the construction was completed by ADT Workplace.
Liverpool Community Health NHS Trust delivers community based health care to over 750,000 people across Merseyside and aims to become one of the first Community Foundation Trusts, meaning the Trust will be more accountable to the local communities.
Bernie Cuthel, chief executive of Liverpool Community Health, said: "Our decision to relocate to Liverpool Innovation Park was based largely on our drive to innovate and fully sustain our resources for the benefit of our patients, staff, volunteers and members.
"A huge and important organisational change is the move towards agile and flexible working.
"The state of the art facilities and prominent location at Liverpool Innovation Park will enable us to continue delivering high quality care for our communities."
CBRE was project manager and ADT Workplace was the contractor.
Liverpool Innovation Park is operated by Space Northwest, a joint venture between Ashtenne Industrial Fund & the Homes and Communities Agency.
DTZ advised Ashtenne on the deal.
The park is part funded by the European Regional Development Agency.