Proposals to build up to 400 properties on a 42-acre site in Farington have been lodged by the Homes & Communities Agency with South Ribble Council.
The scheme in Croston Road North will take up to 10 years to complete and includes a new link road and the potential for leisure facilities. The HCA said the proposed layout was designed to accommodate existing ecological features to create a network of open spaces as part of the development.
Up to 400 new houses, including affordable properties, would be built under the plans as well as a link road to access the development and connect to the wider area.
There will also be the potential to accommodate new leisure facilities. Subject to planning approval, the site will be marketed to developers early next year.
Marie Hodgson, head of area for the HCA in Lancashire and Cumbria, said: "This application is a vital part of making the Croston Road North scheme appealing to potential developers.
"It has been identified as a major development site locally and is also part of the Preston, South Ribble and Lancashire City Deal, so accelerating the delivery of the site with strong local partnership working is essential."