Holland & Barrett, trading under the name of H&B Outlet, has taken a 1,196 sq ft ground floor unit at The Lowry Outlet Mall in Salford Quays.
H&B Outlet will be situated between Camille Lingerie and Bijoux Jewellery on the ground floor of the Mall and is scheduled to open on Wednesday 18 August.
The store is expected to stock a range of vitamins, supplements, foods and sports nutrition products.
The Lowry Outlet Mall is owned by Emerson and neighbours The Lowry arts centre and Imperial War Museum North, while Peel's Media City UK is also located nearby, across the River Irwell.
Rob Hallworth, centre manager, said: "It's an exciting time for the Mall and for the area as a whole, we've created a 'golden triangle' of retail, leisure and business sectors – MediacityUK, The Lowry Theatre/Lowry Outlet Mall and the Imperial War Museum North – and we're sure H&B Outlet will benefit hugely from being a part of this."
H&B Outlet joins other tenants including Dickies, Bijoux and Gap Outlet at the Mall. Details of the rental agreement were not disclosed.