The German IT firm has signed a lease on a 1,743 sq ft office within the Blue Tower at Peel's Salford Quays development.
Grenke Leasing has offices across Europe and specialises in leasing office communication and IT equipment to small and medium-sized companies.
Blue Tower is located above The Studios at Media City UK.
Stefan Zeeh, director of sales international at Grenke, said: "We are delighted to open our 5th UK Sales office at Media City UK. The location and prestigious development is a perfect fit for Grenke's continued UK and European expansion."
The company was set up in 1978 in Baden-Baden, southern Germany. Details of the rental agreement was not disclosed.