The Travellers Rest on Crab Street, north of the town centre, closed in 2008 before being demolished. Plans to build 61 apartments at the site have now been submitted to the council.
Liverpool-based architect MBED Architects has drawn up proposals for a two-block apartment scheme on behalf of the applicant, named as Mrs A Newell on the planning documents.
The applicant owns the land, but it is understood that the site will be marketed for sale subject to planning consent being secured.
Mark Bennett, director of MBED Architects, said he expects the apartments would be developed on an affordable basis, to be built and operated in conjunction with a registered social housing provider.
Bennett said: “We had very positive pre-application discussions with St Helens Council, which is proactive in making things happen.”
He added that the council had stipulated that the project must provide one parking space for each flat, which could limit the size of the development.
On College Street, close to the development site, a collection of former HM Revenue & Customs buildings have extant planning consent for 68 flats.