Carlisle farmer Gordon Brown has been given consent to legally challenge the city council's decision to grant planning permission for the redevelopment of the local airport.
Brown's second appeal, following one in July, for a judicial review into the decision was thrown out by the High Court in October.
However, that ruling has now been overturned by the Court of Appeal in London.
The ruling could be a blow to Stobart Group, which owns the lease on the airport, and to Carlisle City Council.
If the challenge succeeds, the court could order the council to withdraw the planning permission.
Brown, who is from Irthington and owns Lane End Farm opposite the Crosby-on-Eden airfield, says the plans should have been referred to the Government Office for the North West as a departure from planning policy.
Stobart plans a new head office and distribution centre plus alongside a new terminal. The £25m scheme was approved last December.
The judicial review hearing will be held in the Court of Appeal next year.