Amongst the lots at Smith & Sons final auction of 2012 will be the former home of Andrew 'Sandy' Irvine, who died near the summit of Mount Everest in 1924.
The event will be held on 5 December at 2pm at the Village Hotel in Bromborough, Wirral.
Irvine's old detached Victorian house at 54-56 Park Road South was previously used as a Cooperative workers' club, and more recently the ESWA Sports and Social Club. The house has a guide price of £350,000-£375,000.
Chris Johnson, auctioneer at Smith & Sons, said: "This property has lots of potential and is in a prime location for redevelopment. The building sits within 1.3 acres of Birkenhead Park.
"It's great to have a lot included that holds a good deal of local historical significance and we are anticipating this to generate a lot of interest."
Also up for auction are a number of houses in need of refurbishment with potential rental income, as are two, five and six bedroomed houses already let and producing returns of 12%-14%.
A grade-1 office building in Hamilton Square, with five car parking spaces but in need of some refurbishment, is offered at a guide of £140,000.
Two retail commercial investments in high street positions in Prenton and Wallasey are offered, producing a yield of 13%.
Also available is a detached workshop and office in Hoylake and a two storey, 9,400 sq ft, industrial unit in Forest Road, Southport, with a guide of £175,000-£195,000.
Johnson added: "2012 has been a challenging year and the on-going issues that have faced the industry continue to impact on the level of buying and selling. With some small, positive signs already emerging, any purchases made now will prove to be excellent buys."