EasyJet will begin a three-times-weekly service from Liverpool John Lennon Airport to Gibraltar in spring 2011.
The airline will operate the new route from 29 March with fares starting at £27.99 one-way, including taxes.
Robin Tudor, had of public relations at the airport, said: "This will be the first time scheduled flights will be available to Gibraltar for the region's passengers direct from Liverpool John Lennon Airport and we expect this unique destination to be yet another easyJet success.
"At a time when many airlines are consolidating their business across the UK, it is great to see easyJet continuing to develop services from here.
EasyJet now flies to 33 destinations from Liverpool John Lennon Airport including recently launched routes to Brussels, Salzburg and Tallinn.