The development of a University Technical College in Crewe being funded by an £11m grant from the Department for Education is due to be approved by Cheshire East Council.
The council will consider the plans, designed by IBI Group, at a meeting of its Southern planning committee on Wednesday 25 November.
The Crewe Engineering & Design UTC will train 800 students aged 14-19 who want to pursue careers in industries like automotive, rail and advanced manufacturing.
It will be built on the site of the former Victoria Community High School on West Street.
The 3.2 acre site is made up of three buildings constructed in the 1980s. The development will see the demolition of former school buildings Newdigate and Meredith Buildings to make way for a three-storey 40,000 sq ft educational building, and the refurbishment of the Oakley Building.
Cheshire East Council is the applicant for the scheme.
The UTC, due to open in September 2016, is a partnership between Cheshire East Council, Bentley Motors, Manchester Metropolitan University, Siemens, Bosch, OSL Rail, Jacobs Engineering, Chevron Racing, Optical 3D and South Cheshire Chamber of Commerce.
At the same planning meeting, council officers are set to approve the development of 40 homes on a greenfield site at Yew Tree Farm, near Alsager. The development by Muller Strategic Projects is next to a site which was granted planning permission on appeal for 74 homes earlier this year. The project will be approved subject to an agreement to deliver 30% affordable housing.
The council is also expected to grant reserved matters consent to 110 homes by Persimmon Homes at Crewe Road, also near Alsager.