Salford City Council has rejected a planning application by Sky Properties to build a £70m waste recycling centre.
The developer will appeal to the Department for Communities and Local Government to review the decision by councillors to reject the local planning officers' recommendations to approve the plans.
Anthony Hirsch, director of Sky Properties, said: "The council officers were satisfied that all technical questions had been answered and that our plans met government policy and guidelines. There is still an opportunity for Salford to benefit from proven technology delivering environmental and economic benefits, including 60 jobs.
"We are still committed to investing in the site and working with the council, businesses and the local community."
The plans were opposed by certain local residents on air quality and congestion grounds.
Sky Properties argued that the Green Lane Eco Park offered a more cost-effective and environmentally responsible way of managing local business waste, reducing waste being transported to landfill sites across the region.