Commercial property advisor CBRE has agreed a 10-year lease for 2,572 sq ft on the sixth floor of No. 4 St Paul's Square in Liverpool city centre.
English Cities Fund, a joint venture between Muse Developments, Legal & General Property and the Homes & Communities Agency completed the building last year.
The office is also home to Santander Corporate, which recently took 14,155 sq ft at a headline rent of £20/sq ft.
Phil Mayall, development director of English Cities Fund, said: "This is an example of yet another private sector occupier choosing to locate within St Paul's Square. We are looking forward to announcing further lettings shortly, including exciting interest in our ground floor units."
Mark Worthington, director of CBRE, said: "No. 4 St Paul's Square is an impressive building and, after considering the various alternatives, we regard it as being the building that best reflects the contemporary and forward-thinking nature of our company. We plan to be fully in situ in our new premises in mid May."
CBRE is relocating from Castle Chambers, Castle Street.
GVA advised ECF on the deal, whilst CBRE represented itself.