The corporate travel arm of Expedia will take the entire ninth floor of Three Piccadilly Place, 12,700 sq ft, on a 10-year lease at £25/sq ft.
Egencia joins law firm Weightmans, consultant EC Harris, the NHS Strategic Health Authority, and conferencing and serviced office provider Orega at the 670,000 sq ft, office, retail, hotel and residential complex.
Egencia's new Manchester office will be home to up to 200 members of staff. Andrew Clarke, director of customer service at Egencia, said: "Three Piccadilly Place met our desire to select a highly distinctive and well-located office building for Egencia and places us in a pivotal position in one of the UK's most important office locations.
"The combination of high build standards and excellent transport links makes it the ideal location for our company."
Jonathan Baucher of Cushman & Wakefield represented Egencia. He said: "Following an extensive search, the location was a real attraction due to its proximity to their current premises and connectivity to Manchester Piccadilly Station."
He added that the deal represents one of the largest transactions in the new build market this year.
Ben Du Boulay, director of The Carlyle Group, said: "Egencia is a thriving and respected company, and great addition to the roster of tenants at Three Piccadilly Place.
"They have shown a real commitment to improving their Manchester offices and we are delighted that the high quality, centrally located space at Piccadilly Place has met their aspirations."
Chris Cheap, director of property consultants GVA, who advised The Carlyle Group, said: "Egencia is a vibrant company who really care about their staff, because of this they were not only drawn to the well specified efficient office space on offer at Piccadilly Place, but in addition the various initiatives that have been put in place by The Carlyle Group and the management team to make the scheme the best working environment within the city."
Three Piccadilly Place was developed by Argent and bought by The Carlyle Group in 2008.
Savills and GVA are joint advisors to The Carlyle Group. Cushman & Wakefield advised Egencia.