Campus Living Villages has agreed a nine-year lease on 2,600 sq ft of office space on the eighth floor of Peel's Quay West building at MediaCityUK.
The company owns and manages student accommodation and communities with 35,000 customers worldwide.
Rob Moyle, chief operating officer at CLV UK, said: "CLV is a rapidly expanding business in the UK.
"With a strong development pipeline across the country, Quay West provided a good base for a regional office to support our London team and to continue delivering innovative student accommodation solutions across the UK."
Liza Marco, property asset manager at Quay West, said: "The arrival of CLV to MediaCityUK is excellent news and will add to the already diverse range of companies located here."
CBRE and Edwards & Co act for Peel.