The Manchester-based property company has agreed a five-year £300m funding facility with the Royal Bank of Scotland, Barclays, Santander and HSBC.
Bruntwood employs around 500 people, and is active in Manchester, Liverpool, Leeds and Birmingham.
The family-owned company is the majority shareholder in Manchester Science Partnerships, which bought the 400-acre Alderley Park in Cheshire earlier this year and is involved in a series of developments along the Oxford Road corridor in Manchester.
Bruntwood has refinanced £600m of facilities in the last two years.
All banks in the deal were joint lead arrangers, lenders and hedge providers and RBS also acted as co-ordinator, agent and security trustee.