Boots is relocating within Park Lane Estates' Stamford Quarter in Altrincham to become the anchor tenant in the second phase of its redevelopment.
The health and beauty retailer has taken 21,000 sq ft over two floors and is due to open its new store in the autumn.
Boots was previously located at Stamford Square on George Street. The second phase of the £40m revamp of Stamford Quarter opens shortly with a remodelled car park and ten extra shops totalling 75,000 sq ft.
Phase One opened in 2007 with tenants such as Desire by Debenhams, Next, Waterstones and Orange.
The overall scheme will create 146,000 sq ft of new retail space and 203,000 sq ft of refurbished space.
Tushingham Moore and Lunson Mitchenall are letting agents.