Hazel Blears, Secretary of State for Communities and Local Government, has approved the compulsory purchase of land and buildings to make way for two major developments in Openshaw, east Manchester.
The first development, valued at £60m, will see 400 new family homes replace a terrace of houses in the Toxteth Street area of Openshaw.
The second is a £40m district centre by Dransfield Properties with a Morrison's supermarket, shops, offices and a health centre to be built nearby on Ashton Old Road, Openshaw.
Eddie Smith, chief executive of New East Manchester, said: "Confirmation of the compulsory purchase orders means we can now continue to turn into action the Neighbourhood Plan for the area, which is based on years of consultation and close working with local people.
"It will transform an area with a long-standing history of poor quality housing, a poor environment and problems with crime into a sustainable family-focussed area where people will choose to live."