Bury-based Barnes Construction has been appointed by Level Healthcare to design and build a £4.8m health centre on Bury New Road.
The 38,000 sq ft facility will include a GP surgery, consulting rooms, nurse stations, offices, minor operations suites and an adjoining Tesco Express, pharmacy and optician.
Work is due to start at the end of September, with the centre expected to be completed in autumn 2015.
In Manchester, Barnes has also started on site at an extension to St Mary's Hospital to house the IVF department. Barnes was appointed by Central Manchester University Hospitals NHS Foundation Trust. The architect for the scheme is IBI Group.
Barnes Construction, formerly known as Thomas Barnes & Sons, is headquartered in Bury with offices in Liverpool, Leeds and Birmingham.
Current projects include FC United's stadium in Moston, Blackburn Bus Station, Islington Wharf apartments at Ancoats and Bowland High School.