Lane End Developments has gained planning permission for the construction of 60 homes on behalf of Adactus Housing Group in Stretford.
The £6.3m scheme at Warwick Street South is due for completion in November 2016.
Huyton-based contractor Mellwood has been appointed to build the project.
Warwick Street South is part of a wide portfolio of developments that Lymm-based Lane End Developments is delivering across the North West for registered housing providers.
Richard Harrison, managing director of Lane End Developments, said: “This development will bring much needed housing to the area, building on a redundant and derelict commercial site. We are delighted to be part of that.”